Endocrine Abstracts

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Both type 1 and 2 diabetes are associated with an increased fracture risk. Whereas in type 1 bone fragility is mostly explained by a lower peak bone mass and low bone turnover state, which is a common feature of several chronic and/or inflammatory diseases starting during growth, in type 2 diabetes there is not necessarily low bone mass, rather a higher aBMD related to overweight/obesity in these subjects. To explain the increased propensity to fractures in this case, a higher...

The RANK/RANK ligand (RANKL) pathway is key to promote osteoclast formation and activation, and prolong osteoclast survival. Osteoprotegerin (OPG) acts as a decoy receptor for RANKL and prevents its interaction with RANK thereby inhibiting osteoclast formation, function and survival. In turn RANKL inhibitors, and more specifically a human monoclonal antibody against RANKL, Denosumab, have been developed to treat a variety of bone disorders, including osteoporosis and skeletal ...